I've only been around a few v-four Hondas. I synched a set of carbs on the 500 Interceptor. It was a pain in the bum. Same procedure as any other multi, just that with the carbs being tightly nestled in the V, makes getting to the adjustment screws a pain, or ummmm,,, more of a pain than many of the in-line motors can be. Adjust the valves on the v-fours is a more of a pain too. Again, the adjusting itself isn't really any different than others, just with that V, a bit more labor intensive to get to it all. I think that is the jist of it, when some fellas talk about them being a pain to work on.