Josh, I see that ad is gone, but here's the lowdown between R5's and RDs. Often people not in the know will mistake the two as the same because they look so close.
The main differences between the R5 and RD350's are as follows:
Brakes: Front disc on RD, drum both ends on R5
Tranny: 5-speed on R5, 6-speed on RD
Intake/Engine: R5 = Piston port with no reed valve intake;
RD = 7 transfer port cylinders, with reed valve intake
Carbs: Don't have everything memorized, but I do know the cutaway on the slide is different: one is 2.5, the other 2.0. I should look in my manual(s) but too lazy right now!
The R5 also has a steering dampener of sorts at the triple clamp.
My BF's first bike was a '72 R5. He's had many RDs since then, and says the piston port R5 engine is even more peaky than an RD.
The good news, is the engine case/internals are fully interchangable.
That is, you can take a 6-speed tranny and drop it right in an R5 case. You can also leave the tranny alone, a slap an RD motor (if you also have the reed cages) onto an R5 bottom end. I don't know if the fork and stem dimensions are the same so as to put a disk front wheel on an R5 but it's probably a good bet you can do so.
If anyone else out there knows of other differences I haven't thought of, feel free to let him know.