Yeah I kind of lean towards a little less power and more durability.... I'm not making, nor will I ever make, a living doing this stuff.
My heads are being redone with Ampco 45 guides and one piece SS valves. Mich Rich is doing the work and he pretty much talked me out of the 4mm valves. With the valve train problems that 350's are noted for I'm guessing Chris went with 4mm to reduce mass. That would then require less valve spring pressure and would help the rockers, cam and cam bearings last longer. Or I guess you could keep the same pressures and go to higher rpm before float. The 350 also has a larger valve, so more contact area with the seat to disapate heat, but that trade off gets complicated cause the larger valve soaks up more heat too.
The problem is you can only get so much air in and out of these old two valve engines. So when you are maxed out in breathing and compression you have to look for rpm. A little 175 like mine with a 41mm stroke is good to about 16,000 rpm before you hit piston speed problems. Yes the crank and rods would probably take the rpm...not likely the valve train would take more than 13,000. So that's the weak point, and one that's difficult...or rather..very expensive to solve. Ti valves would certainly help, then you are talking exotic stellite seats and such.
I'd be more inclined to build a freakin Ti frame, magnesium brakes etc to get the chassis as light weight as possible...see you don't often blow up your frame or brakes

Spend the money once, use many times. Unlike exotic engines which often seem to be spend the money once, use the engine twice.
JohnnyB